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HPF1 protein, human (Histone PARylation factor 1, C4orf27)

HPF1 protein, human

Description: HPF1 protein, human, Cat. #2097, is highly purified and active recombinant full-length human HPF1, expressed in E. coli.  The purified protein does not contain any expression tags.  Please see the datasheet for additional information.


Supplied as: 50µg HPF1 protein, human, lyophilized or 0.5mg (1mg/mL).


Price:

Cat. #2097 (lyophilized) 50µg/$200; 5 x 5µg/$800 (shipped on blue ice or RT)

Cat. #2097/S (1mg/mL) 0.5mg/$1000; 5 x 0.5mg/$4000 (shipped on dry ice)

Please contact us for custom packaging and larger quantities.


Background: Mono- and poly-ADP-ribosylation are catalyzed by poly (ADP-ribose) polymerase (PARP) family proteins.  PARP1/2 plays a critical role in the SSBR, and DSBR, the regulation of the stability of DNA replication forks, and maintenance of chromatin structures. Upon DNA damage, PARP1 rapidly recognizes and binds to a nicked or a gapped single-stranded DNA break which activates autoPARylation. Various PARP1-interacting regulatory factors play a role in the regulation of PARP1 activity. In response to DNA damage, histone PARylation factor 1 (HPF1 ; C4orf27) directly binds to the catalytic domain of PARP1/2 and promotes ADP-ribosylation at serine residues of PARP1, histone proteins, and other chromatin-associated factors. The serine-ADPr is a major and reversible post-translational modification in cells in response to DNA damage.


Gibbs-Seymour I, et al. (2016) Mol Cell. 62 432 doi.org/10.1016/j.molcel.2016.03.008


#2097 Quantity


recombinant HPF1